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Our lab is interested in the systems biology and evolution of epigenetic switches (bistability) and clocks (oscillators) in gene regulatory networks. We use experiment and theory, biology and physics, systems and synthetic biology to study the cell cycle, metabolic rhythms, and circadian clocks. How do oscillators with different frequencies co-exist in the same cell? Are there mechanisms and regulatory principles that ensure functional harmony between oscillators?

Selcan and Tony defend their PhDs

selcantony-defense2017Tony Burnetti and Selcan Aydin defended their dissertations on back-to-back days! Double congrats to these new PhDs posing with Selcan’s magnum of champagne.

Tony defended his dissertation on the “Coupling of the Yeast Metabolic Cycle and the Cell Division Cycle in Populations and Single Cells“. Tony’s committee was Paul Magwene (Biology), Amy Schmid (Biology), Philip Benfey (Biology), and Nicolas Buchler (Biology & Physics). Tony is now a University Program in Genetics & Genomics PhD.

Selcan defended her dissertation on “Understanding the Effects of Genetic Variation on Osmo-adaptation Dynamics Across Saccharomyces cerevisiae using Bulk Segregant Analysis and Whole Genome Sequencing“. Selcan’s committee consisted of Paul Magwene (Biology), Tom Mitchell-Olds (Biology), John Willis (Biology), Amy Schmid (Biology), Danny Lew (Pharmacology & Cancer Biology), and Nicolas Buchler (Biology & Physics).  Selcan is now a Biology PhD.

Mariana defends PhD thesis

marianaMariana Gomez-Schiavon successfully defended her dissertation on “Stochastic Dynamics and Epigenetic Regulation of Gene Expression:  From Stimulus Response to Evolutionary Adaptation“. Congratulations!  Mariana is now a Computational Biology & Bioinformatics Ph.D.

Her committee was Katia Koelle (Biology), Ryan Baugh (Biology), Joshua Socolar (Physics), and Nicolas Buchler (Biology & Physics).