Our lab is interested in the systems biology and evolution of epigenetic switches (bistability) and clocks (oscillators) in gene regulatory networks, two functions that are essential for proper patterning, cell proliferation, and cellular differentiation in biological systems.
The Buchler lab welcomes the Duke 2014 iGEM team (Anthony Ciesla, Matthew Farnitano, Matthew Faw, Delta Ghoshal, Garima Tomar, Janan Zhu, Mike Zhu). These Duke undergraduates and NCSSM high-school students are building synthetic switches and oscillators in bacteria using CRISPRs.
From left to right: Nick Buchler (bottom), Charlie Cooper, Garima Tomar, Matt Faw (top), Anthony Ciesla, Delta Ghoshal, Matt Farnitano, Charlie Gersbach, and Mike Zhu
The lab welcomes Mitch, who is working closely with Sargis Karapetyan and the summer Duke GEM club. Read about Mitch’s summer project on synthetic oscillators and switches in bacteria at Duke Today.
Sargis presented his latest work “Mathematical modeling reveals additional links between the circadian clock and the redox rhythm in Arabidopsis through a master immune regulator” at the 2014 Society for Research on Biological Rhythms meeting in Big Sky, Montana. This is a collaboration with Mian Zhou, Wei Wang, and Xinnian Dong at Duke University.