Sargis defends PhD thesis

sargis-defenseSargis Karapetyan successfully defended his dissertation on “Design principles and coupling of biological oscillators”. Congratulations!  Sargis is now a Physics Ph.D.

His committee was Joshua Socolar (Physics), Gleb Finkelstein (Physics), Berndt Mueller (Physics), Xinnian Dong (Biology), and Nicolas Buchler (Physics & Biology). Here’s a picture of Sargis with Armenian brandy (after the thesis).

Buchler lab at 2015 Summer q-bio

StJohns-q-bioOur lab was out in full force at the Ninth q-bio Conference in Blacksburg, Virginia.

Redox rhythm reinforces circadian clock to gate immune response

Screen Shot 2015-06-22 at 11.09.50This paper combined experiment and theory to demonstrate that newly discovered circadian redox rhythms  regulate the plant circadian clock through NPR1, a master immune regulator. Sargis Karapetyan developed a mathematical model of the plant circadian clock to uncover new regulatory links (red arrows). We learned that NPR1 activates the expression of key circadian clock genes (TOC1, PRR7, LHY) in a “balanced” fashion, such that the amplitude is boosted with no change in period or phase during acute redox perturbation. This was a fun and productive collaboration with the Dong lab.  Read more about it here on the Duke Today website.

Zhou M, Wang W, Karapetyan S, Mwimba M, Marques J, Buchler NE, Dong X. Redox rhythm reinforces circadian clock to gate immune response. Nature 523: 472 (2015)