Gene duplication and co-evolution of G1/S transcription factor specificity

screen-shot-2017-05-23-at-3-41-41-pmRead our latest work that builds upon our growing expertise in cell cycle genomics and the evolution of the G1/S regulatory network in Fungi. This manuscript studied the evolution of duplicated G1/S transcription factors (SBF and MBF) in the budding yeast S. cerevisiae by examining 16 different chimeric transcription factor complexes containing the DNA binding domains from different fungi species. Our data shows that while SBF is the likely ancestral regulatory complex, the ancestral DNA binding element is more MCB-like. G1/S network expansion after gene duplication took place by both cis– and trans– co-evolutionary changes in closely related but distinct regulatory sequences. This was a fun collaboration with Amir Aharoni (Ben Gurion University) and Rob de Bruin (University College London)

Hendler A, Medina EM, Kishkevich A, Abu-Qarn M, Klier S, Buchler NE, de Bruin RAM, Aharoni A. Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing fitness.  PLoS Genetics 13: e1006778 (2017)

Selcan and Tony defend their PhDs

selcantony-defense2017Tony Burnetti and Selcan Aydin defended their dissertations on back-to-back days! Double congrats to these new PhDs posing with Selcan’s magnum of champagne.

Tony defended his dissertation on the “Coupling of the Yeast Metabolic Cycle and the Cell Division Cycle in Populations and Single Cells“. Tony’s committee was Paul Magwene (Biology), Amy Schmid (Biology), Philip Benfey (Biology), and Nicolas Buchler (Biology & Physics). Tony is now a University Program in Genetics & Genomics PhD.

Selcan defended her dissertation on “Understanding the Effects of Genetic Variation on Osmo-adaptation Dynamics Across Saccharomyces cerevisiae using Bulk Segregant Analysis and Whole Genome Sequencing“. Selcan’s committee consisted of Paul Magwene (Biology), Tom Mitchell-Olds (Biology), John Willis (Biology), Amy Schmid (Biology), Danny Lew (Pharmacology & Cancer Biology), and Nicolas Buchler (Biology & Physics).  Selcan is now a Biology PhD.