nsf_logoThe lab has been awarded an NSF grant (“Determine mechanisms of rewiring of the eukaryotic cell cycle by a virus without disrupting network function”) by the Developmental cluster within the Division of Integrated Organismal Systems (IOS).  This builds upon and continues a multi-PI effort with Raluca Gordan, whose lab is adjacent to ours in the Duke Center for Genomic and Computational Biology.

Edgar presents at the 2017 Annual Meeting of the Mycological Society of America

dbz58vbw0aayh7zCongratulations to Edgar Medina for winning a Meredith Blackwell Award for best oral student presentation at the 2017 Annual Meeting of the MSA!  Read more about Edgar’s research and the Blackwell Award.

He gave a talk on “Viral hijacking and evolution of the fungal cell cycle control network: the animal-fungal hybrid network of the zoosporic fungus Spizellomyces“.

Gene duplication and co-evolution of G1/S transcription factor specificity

screen-shot-2017-05-23-at-3-41-41-pmRead our latest work that builds upon our growing expertise in cell cycle genomics and the evolution of the G1/S regulatory network in Fungi. This manuscript studied the evolution of duplicated G1/S transcription factors (SBF and MBF) in the budding yeast S. cerevisiae by examining 16 different chimeric transcription factor complexes containing the DNA binding domains from different fungi species. Our data shows that while SBF is the likely ancestral regulatory complex, the ancestral DNA binding element is more MCB-like. G1/S network expansion after gene duplication took place by both cis– and trans– co-evolutionary changes in closely related but distinct regulatory sequences. This was a fun collaboration with Amir Aharoni (Ben Gurion University) and Rob de Bruin (University College London)

Hendler A, Medina EM, Kishkevich A, Abu-Qarn M, Klier S, Buchler NE, de Bruin RAM, Aharoni A. Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing fitness.  PLoS Genetics 13: e1006778 (2017)