Noisy linear map underlies oscillations in cell size and gene expression in bacteria

Screen Shot 2015-06-05 at 09.03.01Heungwon Park used microfluidics to trap bacteria and measure cell size and gene expression via long-term fluorescence timelapse. Experiments & modelling show that noisy regulation of cell size homeostasis can explain the apparent oscillations we observed in both size and gene expression in bacteria.  This was an amusing collaboration with the laboratory of Lingchong You. Pratt News summary and movie can also be found here.

Tanouchi Y, Pai A, Park H, Huang S, Stamatov R, Buchler NE, You L. “A noisy linear map underlies oscillations in cell size and gene expression in bacteria” Nature 523: 357 (2015).

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