Read our commentary on a series of interesting papers from the Ptashne lab. A novel RSC–nucleosome complex that both strongly phases flanking nucleosomes and presents regulatory sites for ready access has been identified
Read our latest experimental paper that uses a synthetic gene circuit to demonstrate that protein sequestration generates a flexible, threshold response.
We show that molecular titration generates an ultrasensitive threshold response in regulatory networks, both transiently and at steady state. Continue reading